node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VS_2638 | fhs | VS_2638 | VS_II0809 | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.786 |
VS_2638 | fmt | VS_2638 | VS_3127 | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.782 |
VS_2638 | folD | VS_2638 | VS_0889 | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.917 |
VS_2638 | purD | VS_2638 | VS_2952 | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.687 |
VS_2638 | purH | VS_2638 | VS_2951 | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Bifunctional purine biosynthesis protein purH. | 0.735 |
VS_2638 | purN | VS_2638 | VS_2319 | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.778 |
VS_2638 | purU | VS_2638 | VS_2228 | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.604 |
VS_II0816 | fhs | VS_II0816 | VS_II0809 | Glycine cleavage system T protein. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.855 |
VS_II0816 | fmt | VS_II0816 | VS_3127 | Glycine cleavage system T protein. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.781 |
VS_II0816 | folD | VS_II0816 | VS_0889 | Glycine cleavage system T protein. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
VS_II0816 | glyA | VS_II0816 | VS_2373 | Glycine cleavage system T protein. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.988 |
VS_II0816 | glyA-2 | VS_II0816 | VS_II0818 | Glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
VS_II0816 | purD | VS_II0816 | VS_2952 | Glycine cleavage system T protein. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.823 |
VS_II0816 | purH | VS_II0816 | VS_2951 | Glycine cleavage system T protein. | Bifunctional purine biosynthesis protein purH. | 0.834 |
VS_II0816 | purN | VS_II0816 | VS_2319 | Glycine cleavage system T protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.783 |
VS_II0816 | purU | VS_II0816 | VS_2228 | Glycine cleavage system T protein. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.761 |
fhs | VS_2638 | VS_II0809 | VS_2638 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.786 |
fhs | VS_II0816 | VS_II0809 | VS_II0816 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein. | 0.855 |
fhs | fmt | VS_II0809 | VS_3127 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.792 |
fhs | folD | VS_II0809 | VS_0889 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.992 |