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prpB protein (Sideroxydans lithotrophicus) - STRING interaction network
"prpB" - Methylisocitrate lyase in Sideroxydans lithotrophicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate (297 aa)    
Predicted Functional Partners:
Slit_1188
2-methylcitrate dehydratase (495 aa)
 
   
  0.958
Slit_1189
2-methylcitrate synthase/citrate synthase II (382 aa)
   
  0.953
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (655 aa)
   
 
  0.904
Slit_0527
succinyl-CoA synthetase, subunit alpha (293 aa)
         
    0.900
sucC
succinyl-CoA synthetase, subunit beta (389 aa)
         
    0.900
Slit_2126
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (563 aa)
   
 
    0.813
Slit_0807
Homocitrate synthase (380 aa)
   
 
    0.813
Slit_0739
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (511 aa)
   
 
    0.813
Slit_2854
acetyl-CoA carboxylase, biotin carboxyl carrier protein (147 aa)
     
 
    0.810
accD
acetyl-CoA carboxylase, carboxyl transferase, subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (294 aa)
     
 
    0.805
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus, S. lithotrophicus ES-1, Siderooxidans, Siderooxidans lithoautotrophicus, Sideroxydans, Sideroxydans lithotrophicus, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
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