STRINGSTRING
pfp protein (Sideroxydans lithotrophicus) - STRING interaction network
"pfp" - Phosphofructokinase in Sideroxydans lithotrophicus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions (417 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase (548 aa)
   
  0.990
Slit_0113
3-dehydroquinate synthase (546 aa)
   
 
  0.957
Slit_1450
Fructose-bisphosphate aldolase (349 aa)
       
    0.938
Slit_0992
Ketose-bisphosphate aldolase (410 aa)
   
 
  0.926
Slit_0018
Fructose-bisphosphate aldolase, class II, Calvin cycle subtype (354 aa)
   
 
  0.926
Slit_2486
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein (1645 aa)
         
  0.925
fbp
Inositol phosphatase/fructose-16-bisphosphatase (333 aa)
   
  0.921
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (317 aa)
   
  0.920
Slit_0014
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (672 aa)
   
 
  0.917
Slit_1773
ROK family protein (295 aa)
       
  0.910
Your Current Organism:
Sideroxydans lithotrophicus
NCBI taxonomy Id: 580332
Other names: S. lithotrophicus, S. lithotrophicus ES-1, Siderooxidans, Siderooxidans lithoautotrophicus, Sideroxydans, Sideroxydans lithotrophicus, Sideroxydans lithotrophicus ES-1, Sideroxydans lithotrophicus str. ES-1, Sideroxydans lithotrophicus strain ES-1, iron-oxidizing lithotroph ES-1
Server load: low (8%) [HD]