node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT49524.1 | hisA | Msip34_0275 | Msip34_0271 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.794 |
ACT49524.1 | hisB | Msip34_0275 | Msip34_0269 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mfa:Mfla_0251 imidazoleglycerol-phosphate dehydratase. | 0.619 |
ACT49524.1 | hisE | Msip34_0275 | Msip34_0274 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mfa:Mfla_0256 phosphoribosyl-ATP pyrophosphatase. | 0.794 |
ACT49524.1 | hisF | Msip34_0275 | Msip34_0272 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.794 |
ACT49524.1 | hisH | Msip34_0275 | Msip34_0270 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.756 |
ACT49524.1 | hisI | Msip34_0275 | Msip34_0273 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.794 |
ACT49524.1 | tatA | Msip34_0275 | Msip34_0276 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.762 |
ACT49524.1 | tatB | Msip34_0275 | Msip34_0277 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | Twin-arginine translocation protein, TatB subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.732 |
ACT49524.1 | tatC | Msip34_0275 | Msip34_0278 | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | Sec-independent protein translocase, TatC subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.694 |
guaA | hisA | Msip34_1226 | Msip34_0271 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.767 |
guaA | hisF | Msip34_1226 | Msip34_0272 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.514 |
guaA | hisH | Msip34_1226 | Msip34_0270 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.527 |
guaA | tatA | Msip34_1226 | Msip34_0276 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.951 |
guaA | tatB | Msip34_1226 | Msip34_0277 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Twin-arginine translocation protein, TatB subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.951 |
hisA | ACT49524.1 | Msip34_0271 | Msip34_0275 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | PFAM: histidine triad (HIT) protein; KEGG: mfa:Mfla_0257 histidine triad (HIT) protein. | 0.794 |
hisA | guaA | Msip34_0271 | Msip34_1226 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.767 |
hisA | hisB | Msip34_0271 | Msip34_0269 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mfa:Mfla_0251 imidazoleglycerol-phosphate dehydratase. | 0.994 |
hisA | hisE | Msip34_0271 | Msip34_0274 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mfa:Mfla_0256 phosphoribosyl-ATP pyrophosphatase. | 0.996 |
hisA | hisF | Msip34_0271 | Msip34_0272 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisH | Msip34_0271 | Msip34_0270 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mfa:Mfla_0253 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |