STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hden_1070KEGG: pzu:PHZ_p0051 ATP-dependent DNA ligase; TIGRFAM: DNA polymerase LigD, polymerase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; PFAM: DNA primase small subunit. (562 aa)    
Predicted Functional Partners:
Hden_1069
Manually curated; TIGRFAM: DNA polymerase LigD, ligase domain protein; KEGG: azc:AZC_1006 ATP-dependent DNA ligase; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein.
  
 0.999
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.949
Hden_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.883
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.871
Hden_2207
PFAM: protein of unknown function DUF72; KEGG: mes:Meso_1394 hypothetical protein.
 
    0.765
Hden_1255
KEGG: rsp:RSP_2657 exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase.
  
 
 0.625
Hden_2096
PFAM: protein of unknown function DUF892; KEGG: oca:OCAR_5362 hypothetical protein.
 
     0.573
Hden_2622
SMART: beta-lactamase domain protein; KEGG: acr:Acry_1612 exonuclease of the beta-lactamase fold involved in RNA processing-like protein.
 
 0.573
Hden_0754
KEGG: sal:Sala_2779 hypothetical protein.
  
 
 0.572
Hden_1730
SMART: AAA ATPase; KEGG: pla:Plav_3112 DNA replication ATPase.
   
 0.566
Your Current Organism:
Hyphomicrobium denitrificans ATCC 51888
NCBI taxonomy Id: 582899
Other names: H. denitrificans ATCC 51888, Hyphomicrobium denitrificans str. ATCC 51888, Hyphomicrobium denitrificans strain ATCC 51888
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