STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
csl4RNA-binding S1 domain-containing protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (187 aa)    
Predicted Functional Partners:
rrp4
Exosome complex RNA-binding protein Rrp4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
  
 0.999
rrp41
Ribosomal RNA-processing protein RRP41/SKI6; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
  
 0.999
rrp42
3' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
  
 0.999
nep1
Suppressor Mra1 family protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
 
 0.952
Igag_1111
KH domain protein; COGs: COG1094 RNA-binding protein (contains KH domains); InterPro IPR018111:IPR004087:IPR004088:IPR019964; KEGG: hbu:Hbut_1405 putative RNA-processing protein; PFAM: K Homology, type 1, subgroup; SMART: KH domain protein; SPTR: A2BML8 Universally conserved protein; TIGRFAM: KH domain protein; PFAM: KH domain; TIGRFAM: arCOG04150 universal archaeal KH domain protein.
   
  0.937
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
  0.935
Igag_0023
COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR002687:IPR012976; KEGG: hbu:Hbut_0030 ribosomal biogenesis protein - Nop56/SIK1; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; SPTR: A2BIV2 Ribosomal biogenesis protein-Nop56/SIK1; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain.
  
  0.920
Igag_1044
Ribosomal RNA adenine methylase transferase; COGs: COG0030 Dimethyladenosine transferase (rRNA methylation); InterPro IPR001737:IPR020598:IPR020596; KEGG: smr:Smar_0778 dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase; SMART: Ribosomal RNA adenine methylase transferase-like; SPTR: A3DML9 Dimethyladenosine transferase; PFAM: Ribosomal RNA adenine dimethylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
  
   0.919
rps6e
COGs: COG2125 Ribosomal protein S6E (S10); InterPro IPR001377:IPR018282; KEGG: hbu:Hbut_0442 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; SPTR: A2BJZ7 30S ribosomal protein S6e; PFAM: Ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family.
  
 
  0.902
rps4
SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
  0.900
Your Current Organism:
Ignisphaera aggregans
NCBI taxonomy Id: 583356
Other names: I. aggregans DSM 17230, Ignisphaera aggregans DSM 17230, Ignisphaera aggregans str. DSM 17230, Ignisphaera aggregans strain DSM 17230
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