STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
treFCytoplasmic trehalase; Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. (549 aa)    
Predicted Functional Partners:
otsB
Trehalose-6-phosphate phosphatase, biosynthetic; Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
 
 0.980
treC
trehalose-6-P hydrolase; Function experimentally demonstrated in the studied species; enzyme.
  
 
 0.917
treA
Periplasmic trehalase; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system; Belongs to the glycosyl hydrolase 37 family.
  
  
 
0.905
CAR15353.1
6-phospho-glucosidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
  0.900
katE
Hydroperoxidase HPII(III) (catalase); Serves to protect cells from the toxic effects of hydrogen peroxide.
   
  
 0.656
otsA
Trehalose-6-phosphate synthase; Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D- glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose- 6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor; Belongs to the glycosyltransferase 20 family.
 
  
 0.569
glk
Glucokinase; Function experimentally demonstrated in the studied species; enzyme; Belongs to the bacterial glucokinase family.
     
 0.505
pgm
Phosphoglucomutase; Function experimentally demonstrated in the studied species; enzyme.
  
  
 0.465
Your Current Organism:
Escherichia coli UMN026
NCBI taxonomy Id: 585056
Other names: E. coli UMN026
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