| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFG47549.1 | bioB | HMPREF0183_1191 | HMPREF0183_0412 | TIGR03085 family protein. | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | 0.464 |
| EFG48322.1 | bioB | HMPREF0183_0411 | HMPREF0183_0412 | Hypothetical protein. | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | 0.484 |
| argD | bioB | HMPREF0183_1147 | HMPREF0183_0412 | Aminotransferase, acetylornithine/succinylornithine family; COG: COG4992; Pfam: PF00202; InterPro: IPR004636. | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | 0.587 |
| argD | carB | HMPREF0183_1147 | HMPREF0183_1818 | Aminotransferase, acetylornithine/succinylornithine family; COG: COG4992; Pfam: PF00202; InterPro: IPR004636. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.426 |
| argD | lysA | HMPREF0183_1147 | HMPREF0183_0361 | Aminotransferase, acetylornithine/succinylornithine family; COG: COG4992; Pfam: PF00202; InterPro: IPR004636. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.918 |
| bioB | EFG47549.1 | HMPREF0183_0412 | HMPREF0183_1191 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | TIGR03085 family protein. | 0.464 |
| bioB | EFG48322.1 | HMPREF0183_0412 | HMPREF0183_0411 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | Hypothetical protein. | 0.484 |
| bioB | argD | HMPREF0183_0412 | HMPREF0183_1147 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | Aminotransferase, acetylornithine/succinylornithine family; COG: COG4992; Pfam: PF00202; InterPro: IPR004636. | 0.587 |
| bioB | birA | HMPREF0183_0412 | HMPREF0183_1530 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099,PF02237; InterPro: IPR004408. | 0.963 |
| bioB | carB | HMPREF0183_0412 | HMPREF0183_1818 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | 0.490 |
| bioB | folK | HMPREF0183_0412 | HMPREF0183_1266 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.532 |
| bioB | hemD | HMPREF0183_0412 | HMPREF0183_1301 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | uroporphyrinogen-III synthase; COG: COG1587; Pfam: PF00590,PF02602; InterPro: IPR003754; Belongs to the precorrin methyltransferase family. | 0.529 |
| bioB | lysA | HMPREF0183_0412 | HMPREF0183_0361 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.498 |
| bioB | nadE | HMPREF0183_0412 | HMPREF0183_0531 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.582 |
| bioB | tetR | HMPREF0183_0412 | HMPREF0183_1658 | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | Transcriptional regulator, TetR family; Pfam: PF00440; InterPro: IPR012287. | 0.514 |
| birA | bioB | HMPREF0183_1530 | HMPREF0183_0412 | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099,PF02237; InterPro: IPR004408. | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | 0.963 |
| birA | folK | HMPREF0183_1530 | HMPREF0183_1266 | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099,PF02237; InterPro: IPR004408. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.621 |
| birA | nadE | HMPREF0183_1530 | HMPREF0183_0531 | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099,PF02237; InterPro: IPR004408. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.465 |
| carB | argD | HMPREF0183_1818 | HMPREF0183_1147 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Aminotransferase, acetylornithine/succinylornithine family; COG: COG4992; Pfam: PF00202; InterPro: IPR004636. | 0.426 |
| carB | bioB | HMPREF0183_1818 | HMPREF0183_0412 | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family. | Biotin synthase; COG: COG0502; Pfam: PF04055,PF06968; InterPro: IPR013785. | 0.490 |