STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)    
Predicted Functional Partners:
purB
Putative adenylosuccinate lyase; COG: COG0015; Pfam: PF00206,PF08328; InterPro: IPR000362.
 
 0.999
guaB-2
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.992
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695.
  
 0.989
guaB
IMP dehydrogenase family protein; COG: COG0516; Pfam: PF00478,PF00571; InterPro: IPR005991.
 
 
 0.968
guaB3
IMP dehydrogenase family protein; COG: COG0516; Pfam: PF00478; InterPro: IPR001093.
 
 
 0.964
hpt
Hypoxanthine phosphoribosyltransferase; COG: COG0634; Pfam: PF00156; InterPro: IPR005904; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.962
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 
  
 0.932
argG
Argininosuccinate synthase; COG: COG0137; Pfam: PF00764; InterPro: IPR001518; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
   
 
 0.910
pyrB
Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.910
lysC
Aspartate kinase, monofunctional class; COG: COG0527; Pfam: PF00696,PF01842; InterPro: IPR005260; Belongs to the aspartokinase family.
  
 
  0.897
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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