STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5'-phosphate decarboxylase; COG: COG0284; Pfam: PF00215; InterPro: IPR011995; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
 
 0.998
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.997
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 
 0.979
pyrB
Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.966
carB
Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787,PF02142; InterPro: IPR006275; Belongs to the CarB family.
  
 
 0.945
carA
Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family.
 
  
 0.943
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.913
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.907
pyrR
Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
  
 
 0.904
ushA
LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF00149,PF02872,PF00746; InterPro: IPR006179.
    
  0.709
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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