STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metY2Putative O-acetylhomoserine aminocarboxypropyltransferase; COG: COG2873; Pfam: PF01053; InterPro: IPR015421. (291 aa)    
Predicted Functional Partners:
metY
O-acetylhomoserine aminocarboxypropyltransferase domain protein; COG: COG2873; Pfam: PF01053; InterPro: IPR006235.
 
     0.976
metX
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 
 0.967
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.879
EFG46601.1
Methionine synthase, vitamin-B12 independent; Pfam: PF01717.
  
 
 0.879
malY
Aminotransferase, class I/II; COG: COG1168; Pfam: PF00155; InterPro: IPR004839.
   
 0.797
hom
Homoserine dehydrogenase; COG: COG0460; Pfam: PF03447,PF00742,PF01842; InterPro: IPR001342.
  
 
 0.772
cysK
Cysteine synthase A; COG: COG0031; Pfam: PF00291; InterPro: IPR005859; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.766
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
  0.740
ilvA
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
  0.739
EFG48367.1
Aminotransferase, class I/II; COG: COG0436; Pfam: PF00155; InterPro: IPR004839.
   
  0.711
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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