STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)    
Predicted Functional Partners:
sdhA
Succinate dehydrogenase, flavoprotein subunit; Ubiquinone; COG: COG1053; Pfam: PF00890,PF02910; InterPro: IPR011281; overlaps another CDS with the same product name.
 
 0.996
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 0.980
mqo
Malate dehydrogenase (quinone); COG: COG0579; Pfam: PF06039; InterPro: IPR006231.
    
 0.972
EFG46757.1
Hypothetical protein; COG: COG1951; Pfam: PF05681; InterPro: IPR004646; 4.2.1.2.
  
 
 0.970
sdhB
Succinate dehydrogenase iron-sulfur subunit; COG: COG0479; Pfam: PF00111; InterPro: IPR004489; overlaps another CDS with the same product name.
  
 0.949
sdhC
Succinate dehydrogenase, cytochrome b556 subunit; COG: COG2009; Pfam: PF01127; InterPro: IPR014314.
   
 
 0.937
sucC
succinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.912
fahA
FAH family protein; COG: COG0179; Pfam: PF01557; InterPro: IPR011234.
   
 0.903
EFG46635.1
Hypothetical protein; COG: COG2142.
   
 
 0.899
gltA
2-methylcitrate synthase/citrate synthase II; COG: COG0372; Pfam: PF00285; InterPro: IPR002020; Belongs to the citrate synthase family.
  
 0.898
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.