STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (366 aa)    
Predicted Functional Partners:
trpC
Indole-3-glycerol phosphate synthase; COG: COG0134; Pfam: PF00218; InterPro: IPR013785; Belongs to the TrpC family.
 
 0.999
trpE
Anthranilate synthase component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801.
 
 0.999
trpG
Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221.
 
 0.999
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 
 0.997
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.996
hisA
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR010188.
    
 0.966
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.872
pheA
Prephenate dehydratase; COG: COG0077; Pfam: PF00800; InterPro: IPR001086.
 
 
 0.848
menF
Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR005801.
  
  
 0.799
crtB
Phytoene/squalene synthetase; COG: COG1562; Pfam: PF00494; InterPro: IPR002060.
     
 0.716
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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