STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folP-2Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (311 aa)    
Predicted Functional Partners:
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 0.999
folC
Bifunctional protein FolC; COG: COG0285; Pfam: PF08245,PF02875; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family.
 
 0.953
folE
GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474.
 
 
 0.919
folC-2
Bifunctional protein FolC; InterPro: IPR013221.
 
 
 0.813
EFG46682.1
Hypothetical protein; COG: COG1985; Pfam: PF01872; InterPro: IPR002734.
 
   
 0.792
ilvE-2
Aminotransferase, class IV; COG: COG0115; Pfam: PF01063; InterPro: IPR001544.
  
 
 0.765
trpE
Anthranilate synthase component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801.
 
 
 0.619
rbsK
Putative ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
  
 0.587
rihB
Inosine-uridine preferring nucleoside hydrolase; COG: COG1957; Pfam: PF01156; InterPro: IPR001910.
  
    0.571
trpG
Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221.
 
  
 0.510
Your Current Organism:
Brevibacterium mcbrellneri
NCBI taxonomy Id: 585530
Other names: B. mcbrellneri ATCC 49030, Brevibacterium mcbrellneri ATCC 49030, Brevibacterium mcbrellneri str. ATCC 49030, Brevibacterium mcbrellneri strain ATCC 49030
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.