| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFG46296.1 | EFG46560.1 | HMPREF0183_2405 | HMPREF0183_2113 | Non-ribosomal peptide synthetase C-terminal domain protein; COG: COG1020; Pfam: PF00501,PF00550,PF00132; InterPro: IPR012728. | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | 0.666 |
| EFG46296.1 | glyA | HMPREF0183_2405 | HMPREF0183_2092 | Non-ribosomal peptide synthetase C-terminal domain protein; COG: COG1020; Pfam: PF00501,PF00550,PF00132; InterPro: IPR012728. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.886 |
| EFG46560.1 | EFG46296.1 | HMPREF0183_2113 | HMPREF0183_2405 | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Non-ribosomal peptide synthetase C-terminal domain protein; COG: COG1020; Pfam: PF00501,PF00550,PF00132; InterPro: IPR012728. | 0.666 |
| EFG46560.1 | EFG46669.1 | HMPREF0183_2113 | HMPREF0183_2049 | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Hypothetical protein; COG: COG0493; 1.18.1.2. | 0.405 |
| EFG46560.1 | EFG47954.1 | HMPREF0183_2113 | HMPREF0183_0730 | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Metallo-beta-lactamase domain protein; COG: COG0491; Pfam: PF00753,PF00581; InterPro: IPR001279. | 0.611 |
| EFG46560.1 | glyA | HMPREF0183_2113 | HMPREF0183_2092 | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.697 |
| EFG46560.1 | msuE | HMPREF0183_2113 | HMPREF0183_2114 | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Putative FMN reductase; COG: COG0431; Pfam: PF03358. | 0.988 |
| EFG46560.1 | pyrR | HMPREF0183_2113 | HMPREF0183_1813 | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.658 |
| EFG46560.1 | tnp7109-5 | HMPREF0183_2113 | HMPREF0183_2112 | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | Integrase core domain protein; COG: COG2801; Pfam: PF00665; InterPro: IPR001584. | 0.484 |
| EFG46669.1 | EFG46560.1 | HMPREF0183_2049 | HMPREF0183_2113 | Hypothetical protein; COG: COG0493; 1.18.1.2. | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | 0.405 |
| EFG46669.1 | glyA | HMPREF0183_2049 | HMPREF0183_2092 | Hypothetical protein; COG: COG0493; 1.18.1.2. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.483 |
| EFG47954.1 | EFG46560.1 | HMPREF0183_0730 | HMPREF0183_2113 | Metallo-beta-lactamase domain protein; COG: COG0491; Pfam: PF00753,PF00581; InterPro: IPR001279. | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | 0.611 |
| EFG47954.1 | msuE | HMPREF0183_0730 | HMPREF0183_2114 | Metallo-beta-lactamase domain protein; COG: COG0491; Pfam: PF00753,PF00581; InterPro: IPR001279. | Putative FMN reductase; COG: COG0431; Pfam: PF03358. | 0.743 |
| glyA | EFG46296.1 | HMPREF0183_2092 | HMPREF0183_2405 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Non-ribosomal peptide synthetase C-terminal domain protein; COG: COG1020; Pfam: PF00501,PF00550,PF00132; InterPro: IPR012728. | 0.886 |
| glyA | EFG46560.1 | HMPREF0183_2092 | HMPREF0183_2113 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | 0.697 |
| glyA | EFG46669.1 | HMPREF0183_2092 | HMPREF0183_2049 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein; COG: COG0493; 1.18.1.2. | 0.483 |
| msuE | EFG46560.1 | HMPREF0183_2114 | HMPREF0183_2113 | Putative FMN reductase; COG: COG0431; Pfam: PF03358. | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | 0.988 |
| msuE | EFG47954.1 | HMPREF0183_2114 | HMPREF0183_0730 | Putative FMN reductase; COG: COG0431; Pfam: PF03358. | Metallo-beta-lactamase domain protein; COG: COG0491; Pfam: PF00753,PF00581; InterPro: IPR001279. | 0.743 |
| msuE | tnp7109-5 | HMPREF0183_2114 | HMPREF0183_2112 | Putative FMN reductase; COG: COG0431; Pfam: PF03358. | Integrase core domain protein; COG: COG2801; Pfam: PF00665; InterPro: IPR001584. | 0.484 |
| pyrR | EFG46560.1 | HMPREF0183_1813 | HMPREF0183_2113 | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | Luciferase-like monooxygenase, FMN-dependent, CE1758 family; COG: COG2141; Pfam: PF00296; InterPro: IPR011251. | 0.658 |