| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFG48020.1 | aroC | HMPREF0183_0708 | HMPREF0183_1808 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.961 |
| EFG48020.1 | aroE | HMPREF0183_0708 | HMPREF0183_1806 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Putative shikimate dehydrogenase; COG: COG0169; Pfam: PF08501; InterPro: IPR016040. | 0.602 |
| EFG48020.1 | menF | HMPREF0183_0708 | HMPREF0183_2054 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR005801. | 0.926 |
| EFG48020.1 | pheA | HMPREF0183_0708 | HMPREF0183_1414 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Prephenate dehydratase; COG: COG0077; Pfam: PF00800; InterPro: IPR001086. | 0.911 |
| EFG48020.1 | trpC | HMPREF0183_0708 | HMPREF0183_2169 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Indole-3-glycerol phosphate synthase; COG: COG0134; Pfam: PF00218; InterPro: IPR013785; Belongs to the TrpC family. | 0.539 |
| EFG48020.1 | trpD | HMPREF0183_0708 | HMPREF0183_1623 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.539 |
| EFG48020.1 | trpE | HMPREF0183_0708 | HMPREF0183_2172 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Anthranilate synthase component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.911 |
| EFG48020.1 | trpG | HMPREF0183_0708 | HMPREF0183_2244 | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.911 |
| aroC | EFG48020.1 | HMPREF0183_1808 | HMPREF0183_0708 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | 0.961 |
| aroC | aroE | HMPREF0183_1808 | HMPREF0183_1806 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Putative shikimate dehydrogenase; COG: COG0169; Pfam: PF08501; InterPro: IPR016040. | 0.985 |
| aroC | menF | HMPREF0183_1808 | HMPREF0183_2054 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR005801. | 0.947 |
| aroC | pheA | HMPREF0183_1808 | HMPREF0183_1414 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Prephenate dehydratase; COG: COG0077; Pfam: PF00800; InterPro: IPR001086. | 0.951 |
| aroC | trpA | HMPREF0183_1808 | HMPREF0183_2167 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.826 |
| aroC | trpB | HMPREF0183_1808 | HMPREF0183_2168 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.622 |
| aroC | trpC | HMPREF0183_1808 | HMPREF0183_2169 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Indole-3-glycerol phosphate synthase; COG: COG0134; Pfam: PF00218; InterPro: IPR013785; Belongs to the TrpC family. | 0.837 |
| aroC | trpD | HMPREF0183_1808 | HMPREF0183_1623 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.872 |
| aroC | trpE | HMPREF0183_1808 | HMPREF0183_2172 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.979 |
| aroC | trpG | HMPREF0183_1808 | HMPREF0183_2244 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.936 |
| aroE | EFG48020.1 | HMPREF0183_1806 | HMPREF0183_0708 | Putative shikimate dehydrogenase; COG: COG0169; Pfam: PF08501; InterPro: IPR016040. | Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951. | 0.602 |
| aroE | aroC | HMPREF0183_1806 | HMPREF0183_1808 | Putative shikimate dehydrogenase; COG: COG0169; Pfam: PF08501; InterPro: IPR016040. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.985 |