node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADB46759.1 | ADB46760.1 | Acfer_0353 | Acfer_0354 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: dae:Dtox_2299 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | 0.999 |
ADB46759.1 | ADB47636.1 | Acfer_0353 | Acfer_1275 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; KEGG: cdf:CD2335 inosine 5-monophosphate dehydrogenase. | 0.747 |
ADB46759.1 | guaA | Acfer_0353 | Acfer_0670 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.800 |
ADB46759.1 | hslO | Acfer_0353 | Acfer_0357 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hsp33 protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.797 |
ADB46759.1 | ribBA | Acfer_0353 | Acfer_0355 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
ADB46759.1 | ribH | Acfer_0353 | Acfer_0356 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.995 |
ADB46760.1 | ADB46759.1 | Acfer_0354 | Acfer_0353 | KEGG: dae:Dtox_2299 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
ADB46760.1 | ADB47073.1 | Acfer_0354 | Acfer_0681 | KEGG: dae:Dtox_2299 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | PFAM: bifunctional deaminase-reductase domain protein; KEGG: dhd:Dhaf_3920 5-amino-6-(5- phosphoribosylamino)uracil reductase. | 0.626 |
ADB46760.1 | hslO | Acfer_0354 | Acfer_0357 | KEGG: dae:Dtox_2299 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | Hsp33 protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.756 |
ADB46760.1 | ribBA | Acfer_0354 | Acfer_0355 | KEGG: dae:Dtox_2299 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
ADB46760.1 | ribH | Acfer_0354 | Acfer_0356 | KEGG: dae:Dtox_2299 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
ADB47073.1 | ADB46760.1 | Acfer_0681 | Acfer_0354 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: dhd:Dhaf_3920 5-amino-6-(5- phosphoribosylamino)uracil reductase. | KEGG: dae:Dtox_2299 riboflavin synthase, alpha subunit; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | 0.626 |
ADB47073.1 | ADB47636.1 | Acfer_0681 | Acfer_1275 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: dhd:Dhaf_3920 5-amino-6-(5- phosphoribosylamino)uracil reductase. | PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; KEGG: cdf:CD2335 inosine 5-monophosphate dehydrogenase. | 0.432 |
ADB47073.1 | guaA | Acfer_0681 | Acfer_0670 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: dhd:Dhaf_3920 5-amino-6-(5- phosphoribosylamino)uracil reductase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.407 |
ADB47073.1 | ribBA | Acfer_0681 | Acfer_0355 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: dhd:Dhaf_3920 5-amino-6-(5- phosphoribosylamino)uracil reductase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.856 |
ADB47073.1 | ribH | Acfer_0681 | Acfer_0356 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: dhd:Dhaf_3920 5-amino-6-(5- phosphoribosylamino)uracil reductase. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.492 |
ADB47564.1 | ADB47636.1 | Acfer_1203 | Acfer_1275 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; glutaredoxin; KEGG: shi:Shel_18290 anaerobic ribonucleoside- triphosphate reductase. | PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; KEGG: cdf:CD2335 inosine 5-monophosphate dehydrogenase. | 0.566 |
ADB47564.1 | ADB47875.1 | Acfer_1203 | Acfer_1517 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; glutaredoxin; KEGG: shi:Shel_18290 anaerobic ribonucleoside- triphosphate reductase. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.911 |
ADB47564.1 | folE2 | Acfer_1203 | Acfer_1226 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; glutaredoxin; KEGG: shi:Shel_18290 anaerobic ribonucleoside- triphosphate reductase. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.800 |
ADB47564.1 | ribBA | Acfer_1203 | Acfer_0355 | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; glutaredoxin; KEGG: shi:Shel_18290 anaerobic ribonucleoside- triphosphate reductase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.819 |