STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hgdBBenzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] (379 aa)    
Predicted Functional Partners:
hgdA
2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...]
 
 
 
 0.984
hgdC
CoA-substrate-specific enzyme activase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. HgdC (CompA) has a very low ATPase activity, whose the role is to activate dehydratase HgdA-HgdB complex and then maintain an appropriate redox state via an ATP-dependent electron transfer. The dehydratase requires only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) to be functional.
 
 
 0.971
gctB
Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.
 
     0.870
gctA
Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.
 
     0.868
gcdA
Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD).
 
     0.858
ADB46576.1
TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: Protein of unknown function DUF2229, CoA enzyme activase; ATPase BadF/BadG/BcrA/BcrD type; KEGG: bth:BT_1407 activator of (R)-2- hydroxyglutaryl-CoA dehydratase.
 
 
 0.567
ADB48098.1
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dat:HRM2_43390 4Fe-4S iron-sulfur binding protein (ferredoxin).
  
     0.521
ADB48167.1
PFAM: transposase IS4 family protein; KEGG: dsy:DSY1297 hypothetical protein.
       0.457
ADB47898.1
KEGG: ctc:CTC02312 hypothetical protein.
  
     0.453
ADB47945.1
PFAM: protein of unknown function DUF819; KEGG: fnu:FN1585 hypothetical protein.
  
     0.416
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
Server load: low (24%) [HD]