node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADB46576.1 | hgdA | Acfer_0168 | Acfer_1815 | TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: Protein of unknown function DUF2229, CoA enzyme activase; ATPase BadF/BadG/BcrA/BcrD type; KEGG: bth:BT_1407 activator of (R)-2- hydroxyglutaryl-CoA dehydratase. | 2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...] | 0.543 |
ADB46576.1 | hgdB | Acfer_0168 | Acfer_1814 | TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: Protein of unknown function DUF2229, CoA enzyme activase; ATPase BadF/BadG/BcrA/BcrD type; KEGG: bth:BT_1407 activator of (R)-2- hydroxyglutaryl-CoA dehydratase. | Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] | 0.567 |
ADB47898.1 | hgdA | Acfer_1540 | Acfer_1815 | KEGG: ctc:CTC02312 hypothetical protein. | 2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...] | 0.439 |
ADB47898.1 | hgdB | Acfer_1540 | Acfer_1814 | KEGG: ctc:CTC02312 hypothetical protein. | Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] | 0.453 |
ADB47945.1 | hgdB | Acfer_1588 | Acfer_1814 | PFAM: protein of unknown function DUF819; KEGG: fnu:FN1585 hypothetical protein. | Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] | 0.416 |
ADB48098.1 | hgdA | Acfer_1742 | Acfer_1815 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dat:HRM2_43390 4Fe-4S iron-sulfur binding protein (ferredoxin). | 2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...] | 0.487 |
ADB48098.1 | hgdB | Acfer_1742 | Acfer_1814 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: dat:HRM2_43390 4Fe-4S iron-sulfur binding protein (ferredoxin). | Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] | 0.521 |
ADB48167.1 | hgdA | Acfer_1813 | Acfer_1815 | PFAM: transposase IS4 family protein; KEGG: dsy:DSY1297 hypothetical protein. | 2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...] | 0.457 |
ADB48167.1 | hgdB | Acfer_1813 | Acfer_1814 | PFAM: transposase IS4 family protein; KEGG: dsy:DSY1297 hypothetical protein. | Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] | 0.457 |
ADB48167.1 | hgdC | Acfer_1813 | Acfer_1816 | PFAM: transposase IS4 family protein; KEGG: dsy:DSY1297 hypothetical protein. | CoA-substrate-specific enzyme activase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. HgdC (CompA) has a very low ATPase activity, whose the role is to activate dehydratase HgdA-HgdB complex and then maintain an appropriate redox state via an ATP-dependent electron transfer. The dehydratase requires only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) to be functional. | 0.405 |
gcdA | gctA | Acfer_1817 | Acfer_1819 | Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD). | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | 0.938 |
gcdA | gctB | Acfer_1817 | Acfer_1818 | Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD). | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | 0.938 |
gcdA | hgdA | Acfer_1817 | Acfer_1815 | Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD). | 2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...] | 0.881 |
gcdA | hgdB | Acfer_1817 | Acfer_1814 | Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD). | Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] | 0.858 |
gcdA | hgdC | Acfer_1817 | Acfer_1816 | Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD). | CoA-substrate-specific enzyme activase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. HgdC (CompA) has a very low ATPase activity, whose the role is to activate dehydratase HgdA-HgdB complex and then maintain an appropriate redox state via an ATP-dependent electron transfer. The dehydratase requires only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) to be functional. | 0.813 |
gctA | gcdA | Acfer_1819 | Acfer_1817 | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD). | 0.938 |
gctA | gctB | Acfer_1819 | Acfer_1818 | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | 0.999 |
gctA | hgdA | Acfer_1819 | Acfer_1815 | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | 2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...] | 0.878 |
gctA | hgdB | Acfer_1819 | Acfer_1814 | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...] | 0.868 |
gctA | hgdC | Acfer_1819 | Acfer_1816 | Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. | CoA-substrate-specific enzyme activase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. HgdC (CompA) has a very low ATPase activity, whose the role is to activate dehydratase HgdA-HgdB complex and then maintain an appropriate redox state via an ATP-dependent electron transfer. The dehydratase requires only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) to be functional. | 0.788 |