STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hgdCActivator of (R)-2-hydroxyglutaryl-CoA dehydratase; Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen (260 aa)    
Predicted Functional Partners:
hgdB
(R)-2-hydroxyglutaryl-CoA dehydratase subunit beta; Catalyzes the reversible dehydration of 2- hydroxyglutaryl-CoA to glutaconyl-CoA. This is a key step in the fermentation of glutamate; Belongs to the FldB/FldC dehydratase alpha/beta subunit family
  
 0.966
hgdA
(R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha; Catalyzes the reversible dehydration of 2- hydroxyglutaryl-CoA to glutaconyl-CoA. This is a key step in the fermentation of glutamate. It is activated by HgdC; Belongs to the FldB/FldC dehydratase alpha/beta subunit family
 
  
 0.954
gctA
Glutaconate CoA-transferase subunit A; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate
 
     0.906
gctB
Glutaconate CoA-transferase subunit B; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate
 
     0.904
gcdA
Glutaconyl-CoA decarboxylase subunit alpha; Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD)
 
     0.898
Acfer_0168
TIGRFAM: CoA-substrate-specific enzyme activase; PFAM: Protein of unknown function DUF2229, CoA enzyme activase; ATPase BadF/BadG/BcrA/BcrD type; KEGG: bth:BT_1407 activator of (R)-2- hydroxyglutaryl-CoA dehydratase
 
    
0.473
Acfer_0238
PFAM: transposase IS4 family protein; KEGG: dsy:DSY1297 hypothetical protein
       0.434
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans DSM20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
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