STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gctACoenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. (320 aa)    
Predicted Functional Partners:
gctB
Coenzyme A transferase; Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate.
 0.999
gcdA
Carboxyl transferase; Decarboxylase subunit of the primary sodium pump glutaconyl- CoA decarboxylase (GCD).
 
  
 0.938
hgdA
2-hydroxyglutaryl-CoA dehydratase D-component; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropria [...]
 
     0.878
hgdB
Benzoyl-CoA reductase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. Catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-CoA to yield (E)- glutaconyl-CoA. The dehydration mechanism involves a transient one electron reduction of the thioester from (R)-2-hydroxyglutaryl-CoA, generating a ketyl radical. Prior to (E)-glutaconyl-CoA formation, the ketyl radical is subsequently reoxidized by electron transfer back to the HgdA-HgdB complex (CompD) to avoid change in oxidation state of the substrate. The appropriate redox state of dehydr [...]
 
     0.868
hgdC
CoA-substrate-specific enzyme activase; Involved in the fermentation of L-glutamate via the hydroxyglutarate pathway. HgdC (CompA) has a very low ATPase activity, whose the role is to activate dehydratase HgdA-HgdB complex and then maintain an appropriate redox state via an ATP-dependent electron transfer. The dehydratase requires only catalytic amounts of ATP and substoichiometric amounts of HgdC (CompA) to be functional.
 
     0.788
ADB47932.1
PFAM: acyl-CoA dehydrogenase domain protein; Electron transfer flavoprotein alpha subunit; Rubredoxin- type Fe(Cys)4 protein; KEGG: cbi:CLJ_B3073 acyl-CoA dehydrogenase family protein/electron transfer protein.
 
  
 0.549
ADB48353.1
PFAM: regulatory protein IclR; Transcriptional regulator IclR; SMART: regulatory protein IclR; KEGG: aau:AAur_0478 IclR family transcriptional regulator.
 
  
 0.457
ADB46642.1
PFAM: protein of unknown function DUF886; KEGG: tde:TDE2575 hypothetical protein.
  
     0.411
ADB48179.1
KEGG: geo:Geob_3477 penicillin-binding protein 2; TIGRFAM: penicillin-binding protein 2; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain.
  
    0.405
ADB48196.1
PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat; KEGG: ctc:CTC02319 serine/threonine kinase, putative regulatory protein.
 
     0.404
Your Current Organism:
Acidaminococcus fermentans
NCBI taxonomy Id: 591001
Other names: A. fermentans DSM 20731, Acidaminococcus fermentans DSM 20731, Acidaminococcus fermentans str. DSM 20731, Acidaminococcus fermentans strain DSM 20731
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