STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sfla_1036TIGRFAM: malate synthase A; KEGG: sgr:SGR_1297 malate synthase; PFAM: Malate synthase family protein; Belongs to the malate synthase family. (539 aa)    
Predicted Functional Partners:
Sfla_1906
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.987
Sfla_1071
PFAM: AMP-dependent synthetase and ligase; KEGG: sgr:SGR_1334 putative acetyl-CoA synthetase.
   
 0.957
acsA
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.957
Sfla_1527
KEGG: sgr:SGR_1691 putative citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family.
   
 0.948
Sfla_1528
KEGG: sgr:SGR_1692 putative citrate synthase-like protein; TIGRFAM: DNA binding domain protein, excisionase family; PFAM: Citrate synthase.
   
 0.948
Sfla_2673
KEGG: sgr:SGR_3076 citrate synthase 2; PFAM: Citrate synthase; Belongs to the citrate synthase family.
   
 0.948
Sfla_4177
KEGG: sgr:SGR_4826 type II citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
   
 0.948
Sfla_2224
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.940
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 0.935
Sfla_0679
TIGRFAM: acetyl-CoA acetyltransferase; KEGG: sgr:SGR_994 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
 0.929
Your Current Organism:
Streptomyces pratensis
NCBI taxonomy Id: 591167
Other names: S. pratensis ATCC 33331, Streptomyces flavogriseus ATCC 33331, Streptomyces pratensis ATCC 33331
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