STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sfla_2070TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: sma:SAV_3036 hypothetical protein; SMART: metal-dependent phosphohydrolase HD region. (462 aa)    
Predicted Functional Partners:
Sfla_2069
PFAM: Metal-dependent hydrolase HDOD; KEGG: sma:SAV_3035 lipoprotein.
  
0.914
Sfla_1827
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; PAS fold-4 domain protein; GGDEF domain containing protein; KEGG: sgr:SGR_2001 putative integral membrane phosphodiesterase; SMART: GGDEF domain containing protein; PAS domain containing protein; EAL domain protein.
 
 
 0.891
Sfla_1602
GAF sensor hybrid histidine kinase; KEGG: sgr:SGR_1773 putative two-component system sensor kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; histidine kinase HAMP region domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; histidine kinase HAMP region domain protein; response regulator receiver.
  
 
 0.802
Sfla_2326
Diguanylate cyclase with GAF sensor; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein; KEGG: sgr:SGR_2612 putative secreted protein; SMART: GGDEF domain containing protein.
 
 
 0.799
Sfla_2068
KEGG: sgr:SGR_2304 hypothetical protein.
       0.762
Sfla_2072
RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: sgr:SGR_2306 RNA polymerase sigma factor RpoE; TIGRFAM: RNA polymerase sigma-70 factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily.
   
   0.756
Sfla_2071
TIGRFAM: anti-sigma factor; KEGG: sgr:SGR_2305 putative anti-sigma factor.
       0.738
Sfla_2804
Diguanylate cyclase with PAS/PAC and GAF sensors; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; PAS fold domain protein; KEGG: sgr:SGR_4052 hypothetical protein; SMART: GGDEF domain containing protein; PAS domain containing protein; PAC repeat-containing protein; GAF domain protein.
 
 
 0.707
def
Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
       0.697
Sfla_0419
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; GGDEF domain containing protein; PAS fold-4 domain protein; KEGG: sgr:SGR_709 hypothetical protein; SMART: EAL domain protein; GGDEF domain containing protein; PAS domain containing protein; PAC repeat-containing protein.
  
 0.675
Your Current Organism:
Streptomyces pratensis
NCBI taxonomy Id: 591167
Other names: S. pratensis ATCC 33331, Streptomyces flavogriseus ATCC 33331, Streptomyces pratensis ATCC 33331
Server load: medium (76%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.