STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT34438.1Magnesium transporter; Acts as a magnesium transporter. (453 aa)    
Predicted Functional Partners:
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
 0.915
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.833
KRT34439.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.82.
       0.723
KRT35664.1
Putative arabinose 5-phosphate isomerase; KEGG: aco:Amico_1493 2.1e-105 KpsF/GutQ family protein K06041; Psort location: Cytoplasmic, score: 8.96; Belongs to the SIS family. GutQ/KpsF subfamily.
    
 0.535
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
 0.519
purH
KEGG: aco:Amico_1169 4.8e-145 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 9.97.
    
 0.500
KRT34885.1
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.474
KRT34437.1
Hypothetical protein.
       0.472
KRT36190.1
KEGG: aco:Amico_0778 4.7e-60 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
 0.452
KRT36227.1
KEGG: bca:BCE_0044 1.2e-38 purR; pur operon repressor K09685; Psort location: Cytoplasmic, score: 8.96.
     
 0.435
Your Current Organism:
Acetomicrobium hydrogeniformans
NCBI taxonomy Id: 592015
Other names: A. hydrogeniformans ATCC BAA-1850, Acetomicrobium hydrogeniformans ATCC BAA-1850, Anaerobaculum hydrogeniforman DSM 22491, Anaerobaculum hydrogeniforman OS1, Anaerobaculum sp. OS1
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