STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thi4Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (250 aa)    
Predicted Functional Partners:
thiD
Phosphomethylpyrimidine kinase (thiD).
 
  
 0.953
thiC
Thiamine biosynthesis protein (thiC); Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.862
TGAM_1272
ABC transporter, ATP-binding protein, putative; Contains 1 GCN5-related N-acetyltransferase domain.
       0.695
purO
IMP cyclohydrolase (Inosinicase) (IMP synthetase) (purO); Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
       0.615
purC-2
Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase (purC); Belongs to the SAICAR synthetase family.
       0.615
TGAM_1266
Putative carboligase of the ATP-grasp superfamily, C terminal part; N term part is in tg1267. Possibly a true frameshift.
       0.576
TGAM_1267
Putative carboligase of the ATP-grasp superfamily; C term part is in tg1266. Possibly a true frameshift.
       0.576
rbsK
Sugar kinase, putative ribokinase (rbsK); Belongs to the carbohydrate kinase PfkB family.
  
  
 0.575
TGAM_2087
Conserved hypothetical protein; Contains a lambda repressor-like DNA-binding domain and a C-terminal Phosphomethylpyrimidine Kinase (PTHR20858) domain.
 
   
 0.504
cdc48-2
AAA family ATPase, CDC48 subfamily (Cdc48).
    
  0.500
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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