STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
top6AType II DNA topoisomerase VI, subunit A (Top6A); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (386 aa)    
Predicted Functional Partners:
top6B
Type II DNA topoisomerase VI, subunit B (Top6B); Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
 
 
 0.992
eIF1A
eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
 
     0.809
rio1
Protein serine/threonine kinase, RIO1 family (rio1).
       0.800
TGAM_1424
RNA-binding protein, containing KH domain.
       0.800
TGAM_1427
Conserved hypothetical protein; Belongs to DUF530 family.
       0.800
TGAM_1428
Conserved hypothetical protein; Contains 1 Homeodomain-like domain in C-term.
       0.800
TGAM_1429
Conserved hypothetical protein; 4 probable transmembrane helices predicted by modhmm.
       0.800
TGAM_1430
Conserved hypothetical protein; Belongs to DUF198 family.
       0.682
radA
DNA repair and recombination protein RadA (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
   
 
 0.637
radB
DNA repair and recombination protein radB (radB); Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
   
 
 0.633
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.