node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | TGAM_1611 | TGAM_1609 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Imidazoleglycerol-phosphate dehydratase (hisB). | 0.995 |
hisA | hisC-1 | TGAM_1611 | TGAM_0545 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Histidinol-phosphate aminotransferase (hisC). | 0.906 |
hisA | hisC-2 | TGAM_1611 | TGAM_1614 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Histidinol-phosphate aminotransferase (hisC). | 0.993 |
hisA | hisD | TGAM_1611 | TGAM_1608 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisF | TGAM_1611 | TGAM_1612 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Imidazole glycerol phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | TGAM_1611 | TGAM_1607 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.995 |
hisA | hisH | TGAM_1611 | TGAM_1610 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | TGAM_1611 | TGAM_1613 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (HisI); In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | TGAM_1611 | TGAM_1606 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | ATP phosphoribosyltransferase regulatory subunit, putative (HisZ); Based on BLAST alignments, this is second copy of HisS, shorter at C-terminus. The tRNA synthetase class II motives are not detected in this copy. | 0.876 |
hisA | serB | TGAM_1611 | TGAM_0997 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | Phosphoserine phosphatase-like hydrolase, archaeal (serB). | 0.747 |
hisB | hisA | TGAM_1609 | TGAM_1611 | Imidazoleglycerol-phosphate dehydratase (hisB). | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). | 0.995 |
hisB | hisC-1 | TGAM_1609 | TGAM_0545 | Imidazoleglycerol-phosphate dehydratase (hisB). | Histidinol-phosphate aminotransferase (hisC). | 0.991 |
hisB | hisC-2 | TGAM_1609 | TGAM_1614 | Imidazoleglycerol-phosphate dehydratase (hisB). | Histidinol-phosphate aminotransferase (hisC). | 0.999 |
hisB | hisD | TGAM_1609 | TGAM_1608 | Imidazoleglycerol-phosphate dehydratase (hisB). | Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisB | hisF | TGAM_1609 | TGAM_1612 | Imidazoleglycerol-phosphate dehydratase (hisB). | Imidazole glycerol phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | TGAM_1609 | TGAM_1607 | Imidazoleglycerol-phosphate dehydratase (hisB). | ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
hisB | hisH | TGAM_1609 | TGAM_1610 | Imidazoleglycerol-phosphate dehydratase (hisB). | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | TGAM_1609 | TGAM_1613 | Imidazoleglycerol-phosphate dehydratase (hisB). | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (HisI); In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | hisZ | TGAM_1609 | TGAM_1606 | Imidazoleglycerol-phosphate dehydratase (hisB). | ATP phosphoribosyltransferase regulatory subunit, putative (HisZ); Based on BLAST alignments, this is second copy of HisS, shorter at C-terminus. The tRNA synthetase class II motives are not detected in this copy. | 0.864 |
hisB | serB | TGAM_1609 | TGAM_0997 | Imidazoleglycerol-phosphate dehydratase (hisB). | Phosphoserine phosphatase-like hydrolase, archaeal (serB). | 0.779 |