gcvP2 protein (Thermococcus gammatolerans) - STRING interaction network

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gcvP2

Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (502 aa)

Predicted Functional Partners:

gcvT

0.999

gcvH

0.999

gcvP1

0.999

glyA

0.984

kbl

0.930

pdhb

0.918

soxB

0.918

pdha

0.912

soxA

0.912

purD

0.882

Your Current Organism:

Thermococcus gammatolerans

NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
gcvH	gcvP1	TGAM_0903	TGAM_1701	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	0.997
gcvH	gcvP2	TGAM_0903	TGAM_1700	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	0.999
gcvH	gcvT	TGAM_0903	TGAM_0350	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine cleavage system T protein (aminomethyltransferase) (gcvT); The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvH	glyA	TGAM_0903	TGAM_1322	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.979
gcvH	kbl	TGAM_0903	TGAM_2060	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	2-amino-3-oxobutanoate synthase (glycine C-acetyltransferase) (kbl).	0.416
gcvH	purD	TGAM_0903	TGAM_0750	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Phosphoribosylamine--glycine ligase (purD).	0.441
gcvP1	gcvH	TGAM_1701	TGAM_0903	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.997
gcvP1	gcvP2	TGAM_1701	TGAM_1700	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	0.999
gcvP1	gcvT	TGAM_1701	TGAM_0350	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Glycine cleavage system T protein (aminomethyltransferase) (gcvT); The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvP1	glyA	TGAM_1701	TGAM_1322	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.973
gcvP1	kbl	TGAM_1701	TGAM_2060	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	2-amino-3-oxobutanoate synthase (glycine C-acetyltransferase) (kbl).	0.929
gcvP1	pdha	TGAM_1701	TGAM_0357	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Proline dehydrogenase, alpha subunit (pdha).	0.906
gcvP1	pdhb	TGAM_1701	TGAM_0360	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Proline dehydrogenase, beta subunit (pdhb).	0.912
gcvP1	purD	TGAM_1701	TGAM_0750	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Phosphoribosylamine--glycine ligase (purD).	0.610
gcvP1	soxA	TGAM_1701	TGAM_0962	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Sarcosine oxidase, subunit alpha (SoxA).	0.906
gcvP1	soxB	TGAM_1701	TGAM_0961	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	Sarcosine oxidase, subunit beta (SoxB).	0.912
gcvP2	gcvH	TGAM_1700	TGAM_0903	Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	Glycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.999
gcvP2	gcvP1	TGAM_1700	TGAM_1701	Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.	0.999
gcvP2	gcvT	TGAM_1700	TGAM_0350	Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	Glycine cleavage system T protein (aminomethyltransferase) (gcvT); The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvP2	glyA	TGAM_1700	TGAM_1322	Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.	Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.984

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