STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmAPeptidase T1A, 20S proteasome alpha-subunit (psmA); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (260 aa)    
Predicted Functional Partners:
pan
ATP-dependent 26S proteasome regulatory subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP bindin [...]
 
 0.906
TGAM_2038
Ribosome maturation protein SDO1; Shwachman-Bodian-Diamond syndrome (SBDS) related protein, possibly a translation elongation factor EFG/EF2.
 
    0.893
rrp42p
3'-5' exoribonuclease, exosome complex exonuclease 2, Rrp42p-like protein (Rrp42p); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
 
  
 0.833
rrp4p
Exosome complex RNA-binding protein 1, Rrp4p-like protein (Rrp4p); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
 
     0.833
rrp41p
3'-5' exoribonuclease, exosome complex exonuclease 1, Rrp41p-like protein (Rrp41p); Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
  
   0.807
psmB-2
Peptidase T1A, 20S proteasome beta-subunit (psmB); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.800
psmB-1
Peptidase T1A, 20S proteasome beta-subunit (psmB); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.794
rpl15E
LSU ribosomal protein L15E (rpl15E); Belongs to the eukaryotic ribosomal protein eL15 family.
 
  
 0.768
rpl4P
LSU ribosomal protein L4P (rpl4P); One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
 
 
 
 0.747
TGAM_0471
Metal-dependant protease, putative; Belongs to Mov34/MPN/PAD-1 family Contains Jab1/MPN domain.
   
 0.735
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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