node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEI12274.1 | AEI12275.1 | Celgi_1767 | Celgi_1768 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
AEI12274.1 | hisE | Celgi_1767 | Celgi_1763 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | KEGG: xce:Xcel_1730 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like. | 0.890 |
AEI12274.1 | hisG | Celgi_1767 | Celgi_1762 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.807 |
AEI12274.1 | ribA | Celgi_1767 | Celgi_1766 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.999 |
AEI12275.1 | AEI12274.1 | Celgi_1768 | Celgi_1767 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. | 0.999 |
AEI12275.1 | hisE | Celgi_1768 | Celgi_1763 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: xce:Xcel_1730 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like. | 0.869 |
AEI12275.1 | hisF | Celgi_1768 | Celgi_1832 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.469 |
AEI12275.1 | hisG | Celgi_1768 | Celgi_1762 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.900 |
AEI12275.1 | ribA | Celgi_1768 | Celgi_1766 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.999 |
hisA | hisB | Celgi_1975 | Celgi_1980 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | KEGG: imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisD | Celgi_1975 | Celgi_1982 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisE | Celgi_1975 | Celgi_1763 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | KEGG: xce:Xcel_1730 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like. | 0.983 |
hisA | hisF | Celgi_1975 | Celgi_1832 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Celgi_1975 | Celgi_1762 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.992 |
hisA | hisH | Celgi_1975 | Celgi_1976 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Celgi_1975 | Celgi_1828 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | ribA | Celgi_1975 | Celgi_1766 | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.489 |
hisB | hisA | Celgi_1980 | Celgi_1975 | KEGG: imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. | 0.998 |
hisB | hisD | Celgi_1980 | Celgi_1982 | KEGG: imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Celgi_1980 | Celgi_1763 | KEGG: imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | KEGG: xce:Xcel_1730 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like. | 0.984 |