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APAF1 protein (Myotis lucifugus) - STRING interaction network
"APAF1" - Apoptotic protease-activating factor 1 in Myotis lucifugus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (1252 aa)    
Predicted Functional Partners:
CASP9
Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (416 aa)
       
  0.997
CASP3
Caspase 3, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (277 aa)
     
  0.995
BCL2L1
BCL2-like 1 (233 aa)
     
  0.972
CASP8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (481 aa)
     
  0.971
CASP7
Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (269 aa)
       
  0.965
CASP6
Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (278 aa)
       
  0.954
CASP2
Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family (452 aa)
       
  0.950
CASP10
Uncharacterized protein; Belongs to the peptidase C14A family (522 aa)
     
  0.948
ENSMLUG00000015524
Uncharacterized protein; Belongs to the peptidase C14A family (525 aa)
     
  0.948
BIRC8
Uncharacterized protein; Baculoviral IAP repeat containing 8 (497 aa)
     
  0.947
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, Myotis lucifugus, Myotis occultus, little brown bat
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