node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tola_0330 | Tola_1704 | Tola_0330 | Tola_1704 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.805 |
Tola_0330 | Tola_1774 | Tola_0330 | Tola_1774 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aha:AHA_3413 uroporphyrin-III C-methyltransferase. | 0.792 |
Tola_0330 | cysG | Tola_0330 | Tola_2546 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.823 |
Tola_0330 | hemA | Tola_0330 | Tola_0821 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.869 |
Tola_0330 | hemC | Tola_0330 | Tola_3127 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
Tola_0330 | hemE | Tola_0330 | Tola_2593 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.795 |
Tola_0330 | hemH | Tola_0330 | Tola_2212 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.560 |
Tola_0330 | hemL | Tola_0330 | Tola_0579 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: asa:ASA_0797 glutamate-1-semialdehyde-2,1-aminomutase. | 0.992 |
Tola_1704 | Tola_0330 | Tola_1704 | Tola_0330 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.805 |
Tola_1704 | Tola_1774 | Tola_1704 | Tola_1774 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aha:AHA_3413 uroporphyrin-III C-methyltransferase. | 0.909 |
Tola_1704 | cysG | Tola_1704 | Tola_2546 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.953 |
Tola_1704 | hemA | Tola_1704 | Tola_0821 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.696 |
Tola_1704 | hemC | Tola_1704 | Tola_3127 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.981 |
Tola_1704 | hemE | Tola_1704 | Tola_2593 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.914 |
Tola_1704 | hemL | Tola_1704 | Tola_0579 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: asa:ASA_0797 glutamate-1-semialdehyde-2,1-aminomutase. | 0.612 |
Tola_1774 | Tola_0330 | Tola_1774 | Tola_0330 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aha:AHA_3413 uroporphyrin-III C-methyltransferase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: asa:ASA_4302 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.792 |
Tola_1774 | Tola_1704 | Tola_1774 | Tola_1704 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aha:AHA_3413 uroporphyrin-III C-methyltransferase. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: yen:YE2748 putative uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.909 |
Tola_1774 | cysG | Tola_1774 | Tola_2546 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aha:AHA_3413 uroporphyrin-III C-methyltransferase. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.954 |
Tola_1774 | hemA | Tola_1774 | Tola_0821 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aha:AHA_3413 uroporphyrin-III C-methyltransferase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.681 |
Tola_1774 | hemC | Tola_1774 | Tola_3127 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aha:AHA_3413 uroporphyrin-III C-methyltransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.977 |