node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tola_0581 | apaH | Tola_0581 | Tola_2372 | KEGG: har:HEAR2171 hypothetical protein. | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.693 |
Tola_0581 | kdkA | Tola_0581 | Tola_0135 | KEGG: har:HEAR2171 hypothetical protein. | Lipopolysaccharide kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | 0.552 |
Tola_1024 | apaH | Tola_1024 | Tola_2372 | PFAM: peptidylprolyl isomerase FKBP-type; FKBP-type peptidyl-prolyl isomerase domain protein; KEGG: aha:AHA_1261 FKBP-type peptidyl-prolyl cis-trans isomerase FklB. | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.693 |
Tola_1024 | kdkA | Tola_1024 | Tola_0135 | PFAM: peptidylprolyl isomerase FKBP-type; FKBP-type peptidyl-prolyl isomerase domain protein; KEGG: aha:AHA_1261 FKBP-type peptidyl-prolyl cis-trans isomerase FklB. | Lipopolysaccharide kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | 0.552 |
Tola_2371 | apaH | Tola_2371 | Tola_2372 | PFAM: ApaG domain protein; KEGG: vvy:VV0477 ApaG. | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.899 |
Tola_2371 | lptD | Tola_2371 | Tola_2367 | PFAM: ApaG domain protein; KEGG: vvy:VV0477 ApaG. | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | 0.761 |
Tola_2371 | pdxA | Tola_2371 | Tola_2369 | PFAM: ApaG domain protein; KEGG: vvy:VV0477 ApaG. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.821 |
Tola_2371 | rsmA | Tola_2371 | Tola_2370 | PFAM: ApaG domain protein; KEGG: vvy:VV0477 ApaG. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.937 |
Tola_2371 | surA | Tola_2371 | Tola_2368 | PFAM: ApaG domain protein; KEGG: vvy:VV0477 ApaG. | SurA domain protein; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.825 |
Tola_2481 | apaH | Tola_2481 | Tola_2372 | PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: pla:Plav_3460 beta-lactamase domain-containing protein. | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.857 |
apaH | Tola_0581 | Tola_2372 | Tola_0581 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | KEGG: har:HEAR2171 hypothetical protein. | 0.693 |
apaH | Tola_1024 | Tola_2372 | Tola_1024 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | PFAM: peptidylprolyl isomerase FKBP-type; FKBP-type peptidyl-prolyl isomerase domain protein; KEGG: aha:AHA_1261 FKBP-type peptidyl-prolyl cis-trans isomerase FklB. | 0.693 |
apaH | Tola_2371 | Tola_2372 | Tola_2371 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | PFAM: ApaG domain protein; KEGG: vvy:VV0477 ApaG. | 0.899 |
apaH | Tola_2481 | Tola_2372 | Tola_2481 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase; KEGG: pla:Plav_3460 beta-lactamase domain-containing protein. | 0.857 |
apaH | kdkA | Tola_2372 | Tola_0135 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Lipopolysaccharide kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. | 0.715 |
apaH | lptD | Tola_2372 | Tola_2367 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | 0.721 |
apaH | pdxA | Tola_2372 | Tola_2369 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.728 |
apaH | rsmA | Tola_2372 | Tola_2370 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.831 |
apaH | secE | Tola_2372 | Tola_2789 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.698 |
apaH | surA | Tola_2372 | Tola_2368 | Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | SurA domain protein; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.751 |