node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tola_0807 | Tola_0812 | Tola_0807 | Tola_0812 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.935 |
Tola_0807 | Tola_2327 | Tola_0807 | Tola_2327 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; KEGG: asa:ASA_1389 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.921 |
Tola_0807 | guaB | Tola_0807 | Tola_2172 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.929 |
Tola_0807 | guaC | Tola_0807 | Tola_2494 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.910 |
Tola_0807 | purA | Tola_0807 | Tola_2381 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.920 |
Tola_0807 | purH | Tola_0807 | Tola_0541 | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | KEGG: vch:VC0276 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.916 |
Tola_0812 | Tola_0807 | Tola_0812 | Tola_0807 | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.935 |
Tola_0812 | Tola_2327 | Tola_0812 | Tola_2327 | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; KEGG: asa:ASA_1389 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.410 |
Tola_0812 | guaB | Tola_0812 | Tola_2172 | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.944 |
Tola_0812 | guaC | Tola_0812 | Tola_2494 | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.921 |
Tola_0812 | purA | Tola_0812 | Tola_2381 | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.942 |
Tola_0812 | purH | Tola_0812 | Tola_0541 | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | KEGG: vch:VC0276 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.937 |
Tola_0812 | purL | Tola_0812 | Tola_0632 | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.469 |
Tola_2208 | argG | Tola_2208 | Tola_1484 | KEGG: asa:ASA_2510 asparagine synthetase B; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. | KEGG: ent:Ent638_3608 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. | 0.924 |
Tola_2208 | purA | Tola_2208 | Tola_2381 | KEGG: asa:ASA_2510 asparagine synthetase B; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.934 |
Tola_2208 | purL | Tola_2208 | Tola_0632 | KEGG: asa:ASA_2510 asparagine synthetase B; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.569 |
Tola_2208 | pyrB | Tola_2208 | Tola_2803 | KEGG: asa:ASA_2510 asparagine synthetase B; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; KEGG: aha:AHA_4087 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.928 |
Tola_2327 | Tola_0807 | Tola_2327 | Tola_0807 | TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; KEGG: asa:ASA_1389 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; KEGG: ppr:PBPRB0897 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.921 |
Tola_2327 | Tola_0812 | Tola_2327 | Tola_0812 | TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; KEGG: asa:ASA_1389 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: aha:AHA_3546 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.410 |
Tola_2327 | guaB | Tola_2327 | Tola_2172 | TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain protein; fumarate lyase; KEGG: asa:ASA_1389 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.832 |