STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tola_2925KEGG: aha:AHA_3909 periplasmic serine peptidase DegS; TIGRFAM: periplasmic serine protease DegS; PFAM: PDZ/DHR/GLGF domain protein; peptidase S1 and S6 chymotrypsin/Hap; SMART: PDZ/DHR/GLGF domain protein. (366 aa)    
Predicted Functional Partners:
Tola_0844
Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...]
  
 
 0.763
Tola_2924
Protease Do; KEGG: aha:AHA_3908 serine peptidase DegQ; TIGRFAM: protease Do; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; Belongs to the peptidase S1C family.
 
    
0.679
rplI
Ribosomal protein L9; Binds to the 23S rRNA.
 
 
 0.561
Tola_0617
Multi-sensor hybrid histidine kinase; KEGG: aha:AHA_0905 aerobic respiration control sensor protein ArcB; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; Hpt domain protein; PAS domain containing protein.
  
  
 0.540
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
 0.536
Tola_1831
PFAM: carbohydrate kinase FGGY; KEGG: asu:Asuc_0169 carbohydrate kinase FGGY.
   
 0.536
Tola_2184
PFAM: peptidase M16 domain protein; KEGG: asa:ASA_1875 insulinase; Belongs to the peptidase M16 family.
  
 
 0.526
Tola_0483
PFAM: porin Gram-negative type; KEGG: aha:AHA_0463 hypothetical protein.
  
 
 
 0.525
Tola_2471
PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: pla:Plav_3451 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase.
   
 0.525
Tola_0085
TIGRFAM: phage shock protein C; PFAM: PspC domain protein; KEGG: hch:HCH_05445 phage shock protein PspC.
  
  
 0.514
Your Current Organism:
Tolumonas auensis
NCBI taxonomy Id: 595494
Other names: T. auensis DSM 9187, Tolumonas auensis DSM 9187, Tolumonas auensis TA 4, Tolumonas auensis str. DSM 9187, Tolumonas auensis strain DSM 9187
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.