STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
PAC1-2Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs. (454 aa)    
Predicted Functional Partners:
H6BRS1_EXODN
Dynein heavy chain, cytoplasmic.
    
 0.971
H6C9T8_EXODN
NUDE_C domain-containing protein.
    
 
 0.896
H6BJU0_EXODN
Nuclear movement protein nudC.
   
 0.871
H6C7V9_EXODN
Dynein intermediate chain, cytosolic.
   
 0.867
H6BXC7_EXODN
Uncharacterized protein.
    
 0.858
H6C2X1_EXODN
Dynactin 1.
    
 0.843
H6C1H4_EXODN
Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    
 0.825
H6C7Z0_EXODN
Dynein light intermediate chain 1, cytosolic.
   
 0.798
H6BUH4_EXODN
Asparagine synthase (Glutamine-hydrolysing).
    
  0.771
H6C1H5_EXODN
Uncharacterized protein.
    
 0.761
Your Current Organism:
Exophiala dermatitidis
NCBI taxonomy Id: 858893
Other names: E. dermatitidis NIH/UT8656, Exophiala dermatitidis NIH 8656, Exophiala dermatitidis NIH/UT8656, Wangiella dermatitidis NIH 8656
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