STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (276 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Identified by match to protein family HMM TIGR00347.
 
 
 0.998
bioA
Adenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
 0.997
NAMH_0126
8-amino-7-oxononanoate synthase; Identified by match to protein family HMM PF00155.
  
 0.977
NAMH_0314
biotin-[acetyl-CoA-carboxylase] ligase; Identified by match to protein family HMM PF03099; match to protein family HMM TIGR00121.
  
 
 0.945
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.828
NAMH_0114
Sodium/hydrogen exchanger; Identified by match to protein family HMM PF00999.
  
    0.811
NAMH_0111
Phosphodiesterase; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040.
  
    0.803
NAMH_1128
Acetylornithine aminotransferase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00707.
 
 
  
 0.674
NAMH_0109
Cyclic diguanylate phosphodiesterase (EAL) domain protein; Identified by match to protein family HMM PF00563; match to protein family HMM PF02378.
       0.517
hisIE
Histidine biosynthesis bifunctional protein hisIE; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; match to protein family HMM TIGR03188; match to protein family HMM TIGR03456; In the N-terminal section; belongs to the PRA-CH family.
     
 0.498
Your Current Organism:
Nautilia profundicola
NCBI taxonomy Id: 598659
Other names: N. profundicola AmH, Nautilia profundicola AmH, Nautilia profundicola str. AmH, Nautilia profundicola strain AmH, Nautilia sp. AmH, epsilon proteobacterium AmH
Server load: low (36%) [HD]