node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NAMH_0284 | NAMH_0708 | NAMH_0284 | NAMH_0708 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.459 |
NAMH_0284 | NAMH_1531 | NAMH_0284 | NAMH_1531 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.912 |
NAMH_0284 | fmt | NAMH_0284 | NAMH_0313 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.938 |
NAMH_0284 | folD | NAMH_0284 | NAMH_0757 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.970 |
NAMH_0284 | glyA | NAMH_0284 | NAMH_0898 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
NAMH_0284 | purD | NAMH_0284 | NAMH_0852 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | Phosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02655; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM PF08442; match to protein family HMM TIGR00877; Belongs to the GARS family. | 0.999 |
NAMH_0284 | purH | NAMH_0284 | NAMH_0778 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.998 |
NAMH_0284 | purT | NAMH_0284 | NAMH_0399 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.974 |
NAMH_0284 | purU | NAMH_0284 | NAMH_1252 | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.930 |
NAMH_0708 | NAMH_0284 | NAMH_0708 | NAMH_0284 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | 0.459 |
NAMH_0708 | folD | NAMH_0708 | NAMH_0757 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
NAMH_0708 | glyA | NAMH_0708 | NAMH_0898 | Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
NAMH_1531 | NAMH_0284 | NAMH_1531 | NAMH_0284 | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | 0.912 |
NAMH_1531 | folD | NAMH_1531 | NAMH_0757 | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
NAMH_1531 | purT | NAMH_1531 | NAMH_0399 | 5,10-methenyltetrahydrofolate synthetase; Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.902 |
fmt | NAMH_0284 | NAMH_0313 | NAMH_0284 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Identified by match to protein family HMM PF00551. | 0.938 |
fmt | folD | NAMH_0313 | NAMH_0757 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.982 |
fmt | glyA | NAMH_0313 | NAMH_0898 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
fmt | purH | NAMH_0313 | NAMH_0778 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.548 |
fmt | purT | NAMH_0313 | NAMH_0399 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |