node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MSH2 | POLE | ENSCSAP00000009731 | ENSCSAP00000016201 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.827 |
MSH2 | RAD52 | ENSCSAP00000009731 | ENSCSAP00000007870 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | RAD52 homolog, DNA repair protein. | 0.781 |
MSH2 | RNASEH2A | ENSCSAP00000009731 | ENSCSAP00000002852 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.522 |
MSH2 | TOP1 | ENSCSAP00000009731 | ENSCSAP00000010083 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.694 |
MSH2 | TOP3A | ENSCSAP00000009731 | ENSCSAP00000004318 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.537 |
MSH2 | TOP3B | ENSCSAP00000009731 | ENSCSAP00000009886 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.421 |
MSH2 | WRN | ENSCSAP00000009731 | ENSCSAP00000011889 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | WRN RecQ like helicase. | 0.790 |
POLE | MSH2 | ENSCSAP00000016201 | ENSCSAP00000009731 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.827 |
POLE | RAD52 | ENSCSAP00000016201 | ENSCSAP00000007870 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | RAD52 homolog, DNA repair protein. | 0.547 |
POLE | RNASEH2A | ENSCSAP00000016201 | ENSCSAP00000002852 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.874 |
POLE | TOP1 | ENSCSAP00000016201 | ENSCSAP00000010083 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.667 |
POLE | TOP2A | ENSCSAP00000016201 | ENSCSAP00000015255 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.495 |
POLE | TOP2B | ENSCSAP00000016201 | ENSCSAP00000005976 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.494 |
POLE | TOP3A | ENSCSAP00000016201 | ENSCSAP00000004318 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.604 |
POLE | TOP3B | ENSCSAP00000016201 | ENSCSAP00000009886 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.457 |
POLE | WRN | ENSCSAP00000016201 | ENSCSAP00000011889 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | WRN RecQ like helicase. | 0.974 |
RAD52 | MSH2 | ENSCSAP00000007870 | ENSCSAP00000009731 | RAD52 homolog, DNA repair protein. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.781 |
RAD52 | POLE | ENSCSAP00000007870 | ENSCSAP00000016201 | RAD52 homolog, DNA repair protein. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.547 |
RAD52 | RNASEH2A | ENSCSAP00000007870 | ENSCSAP00000002852 | RAD52 homolog, DNA repair protein. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.634 |
RAD52 | TDP1 | ENSCSAP00000007870 | ENSCSAP00000007671 | RAD52 homolog, DNA repair protein. | Tyrosyl-DNA phosphodiesterase 1. | 0.547 |