node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
accC | acs | HTH_1917 | HTH_0077 | Biotin carboxylase. | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.919 |
accC | ccl | HTH_1917 | HTH_0311 | Biotin carboxylase. | citryl-CoA lyase. | 0.922 |
accC | pycA | HTH_1917 | HTH_1452 | Biotin carboxylase. | Pyruvate carboxylase large subunit. | 0.997 |
accC | sucC | HTH_1917 | HTH_1893 | Biotin carboxylase. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.821 |
acnA | acs | HTH_0755 | HTH_0077 | Aconitate hydratase/aconitase. | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.547 |
acnA | ccl | HTH_0755 | HTH_0311 | Aconitate hydratase/aconitase. | citryl-CoA lyase. | 0.955 |
acnA | ccsA | HTH_0755 | HTH_1737 | Aconitate hydratase/aconitase. | citryl-CoA synthetase large subunit. | 0.924 |
acnA | ccsB | HTH_0755 | HTH_0201 | Aconitate hydratase/aconitase. | citryl-CoA synthetase small subunit. | 0.939 |
acnA | icd | HTH_0755 | HTH_0836 | Aconitate hydratase/aconitase. | Isocitrate dehydrogenase; Oxalosuccinate reductase. | 0.989 |
acnA | mdh | HTH_0755 | HTH_0756 | Aconitate hydratase/aconitase. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.915 |
acs | accC | HTH_0077 | HTH_1917 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Biotin carboxylase. | 0.919 |
acs | acnA | HTH_0077 | HTH_0755 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aconitate hydratase/aconitase. | 0.547 |
acs | ccl | HTH_0077 | HTH_0311 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | citryl-CoA lyase. | 0.982 |
acs | icd | HTH_0077 | HTH_0836 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Isocitrate dehydrogenase; Oxalosuccinate reductase. | 0.727 |
acs | mdh | HTH_0077 | HTH_0756 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.683 |
acs | pycA | HTH_0077 | HTH_1452 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate carboxylase large subunit. | 0.857 |
acs | pycB | HTH_0077 | HTH_1598 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate carboxylase small subunit. | 0.838 |
acs | sucC | HTH_0077 | HTH_1893 | Acyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.838 |
ccl | accC | HTH_0311 | HTH_1917 | citryl-CoA lyase. | Biotin carboxylase. | 0.922 |
ccl | acnA | HTH_0311 | HTH_0755 | citryl-CoA lyase. | Aconitate hydratase/aconitase. | 0.955 |