STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
celCPEP-dependent phosphotransferase enzyme III for cellobiose, arbutin, and salicin; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2). (116 aa)    
Predicted Functional Partners:
celA
PEP-dependent phosphotransferase enzyme IV for cellobiose, arbutin, and salicin; Code: G; COG: COG1440.
 
 0.999
celB
PEP-dependent phosphotransferase enzyme II for cellobiose, arbutin, and salicin; Code: G; COG: COG1455.
 
 
 0.999
bglA
6-phospho-beta-glucosidase; Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789267 (104 aa). BLAST with identity of 98% in 103 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct; Belongs to the glycosyl hydrolase 1 family.
 
 
 0.987
celF
Cryptic phospho-beta-glucosidase; Code: G; COG: COG1486.
 
 
 0.980
ptsH
PTS system protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
   
  0.929
ydjC
Conserved hypothetical protein; Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobi [...]
 
   
 0.741
murP
Putative PTS enzyme II; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.
  
  
 0.733
bglF
PTS system beta-glucosides, enzyme II, cryptic.
  
  
 0.729
bglG
Positive regulation of bgl operon.
 
  
 0.720
pfkB
6-phosphofructokinase II; Code: G; COG: COG1105; Belongs to the carbohydrate kinase PfkB family.
  
  
 0.642
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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