STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
let-502Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization (By similarity). (1194 aa)    
Predicted Functional Partners:
rho-1
Protein CBR-RHO-1.
   
 0.995
CBG13699
Protein CBG13699.
   
 0.920
mlc-4
Protein CBR-MLC-4.
    
 0.861
nmy-2
Protein CBR-NMY-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 0.845
nmy-1
Protein CBR-NMY-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 0.842
mel-11
Protein CBR-MEL-11.
   
 0.840
rga-2
Protein CBR-RGA-2.
   
  
 0.818
cdc-42
Protein CBR-CDC-42.
   
 0.811
rhgf-2
Protein CBR-RHGF-2.
    
 0.792
Cbr-mel-11
Protein CBG24954.
   
 0.785
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.