STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
inx-19Innexin-19; Structural component of the gap junctions that specifically coordinates left-right asymmetry in the developing nervous system. Acts by forming gap junction network linking embryonic neurons and providing electrical coupling between cells, leading to promote or inhibit AWC signaling (By similarity); Belongs to the pannexin family. (439 aa)    
Predicted Functional Partners:
nsy-4
Protein CBR-NSY-4.
      
 0.864
srsx-3
Protein CBR-SRSX-3.
      
 0.745
nsy-7
Protein CBR-NSY-7.
      
 0.685
olrn-1
Protein CBR-OLRN-1.
      
 0.665
str-2
Protein CBR-STR-2.
      
 0.665
CBG27201
Protein CBG27201.
      
 0.665
nsy-1
Protein CBR-NSY-1.
      
 0.643
tir-1
Protein CBR-TIR-1.
      
 0.639
unc-43
Calcium/calmodulin-dependent protein kinase type II; Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor (By simil [...]
      
 0.634
die-1
Protein CBR-DIE-1.
      
 0.633
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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