STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
par-1Serine/threonine-protein kinase par-1; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis. (1088 aa)    
Predicted Functional Partners:
par-3
Protein CBR-PAR-3.
    
 
 0.810
par-6
Protein CBR-PAR-6.
    
 
 0.760
par-5
Protein CBR-PAR-5; Belongs to the 14-3-3 family.
    
 0.748
mex-5
Protein CBR-MEX-5.
    
 
 0.711
ftt-2
Protein CBR-FTT-2; Belongs to the 14-3-3 family.
    
 0.685
lgl-1
Protein CBR-LGL-1.
    
 
 0.657
shn-1
Protein CBR-SHN-1.
    
 0.647
pie-1
Protein CBR-PIE-1.
    
 
 0.643
ksr-1
Protein CBR-KSR-1.
  
0.602
lin-45
Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1.
  
0.587
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.