STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cwn-1Protein CBR-CWN-1. (372 aa)    
Predicted Functional Partners:
lin-17
Protein CBR-LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.995
mom-5
Protein CBR-MOM-5; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.995
cfz-2
Protein CBR-CFZ-2; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.995
mig-1
Protein CBR-MIG-1; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.993
sfrp-1
Protein CBR-SFRP-1.
  
 
 0.993
mom-1
Protein-serine O-palmitoleoyltransferase porcupine; Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O- palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle axis.
    
 0.968
mig-14
Protein CBR-MIG-14.
   
 0.952
lin-18
Protein CBR-LIN-18.
    
 0.945
egl-20
Protein CBR-EGL-20.
  
  
0.932
cam-1
Protein CBR-CAM-1.
   
 0.927
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.