STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ced-12Cell death abnormality protein 12; Involved in apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Plays no role in amphid axon outgrowth (By similarity). (740 aa)    
Predicted Functional Partners:
ced-5
Protein CBR-CED-5; Belongs to the DOCK family.
    
 0.999
ced-2
Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity). Belongs to the CRK family.
    
 0.975
CBG26388
Protein CBG26388.
    
 0.957
ced-10
Protein CBG15031.
    
 0.950
ced-6
Protein CBR-CED-6.
      
 0.943
ced-7
Protein CBR-CED-7.
    
 
 0.938
mig-2
Protein CBR-MIG-2.
    
 0.851
abi-1
Protein CBR-ABI-1.
     
 0.804
ced-1
Cell death abnormality protein 1; Involved in programmed cell death/apoptosis. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (By similarity).
    
 
 0.803
ced-8
Cell death abnormality protein 8; Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses.
      
 0.724
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.