STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tph-1Protein CBR-TPH-1. (546 aa)    
Predicted Functional Partners:
bas-1
Protein CBR-BAS-1.
   
 0.987
pcbd-1
Protein CBR-PCBD-1.
  
 0.984
qdpr-1
Protein CBR-QDPR-1.
   
 0.944
tdo-2
Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety (By similarity). Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha-synuclein, via its effects on tryptophan metabolism (By similarity).
  
 
 0.931
cat-2
Tyrosine 3-monooxygenase; Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior (By similarity). Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  
 
0.913
pah-1
Protein CBR-PAH-1.
  
  
 
0.905
dhfr-1
Protein CBG12356; Belongs to the dihydrofolate reductase family.
     
 0.905
CBG20740
Protein CBG20740.
   
 
  0.902
igcm-3
Protein CBR-IGCM-3.
  
 0.850
tdc-1
Protein CBR-TDC-1.
   
 0.842
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.