STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ksr-1Protein CBR-KSR-1. (812 aa)    
Predicted Functional Partners:
mek-2
Protein CBR-MEK-2; Belongs to the protein kinase superfamily.
  
0.908
lin-45
Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has a role in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Positively regulates lifespan upstream of mek-2 and mpk-1.
  
 
0.894
let-60
Protein CBR-LET-60.
   
 0.861
CBG12765
Protein CBG12765.
   
 0.836
ras-1
Protein CBR-RAS-1.
   
 0.815
par-5
Protein CBR-PAR-5; Belongs to the 14-3-3 family.
   
 0.797
ftt-2
Protein CBR-FTT-2; Belongs to the 14-3-3 family.
   
 0.797
cnk-1
Protein CBR-CNK-1.
    
 0.790
Cbr-cnk-1
Protein CBG29116.
    
 0.790
mpk-1
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
   
0.766
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.