STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B0001.2Uncharacterized protein. (926 aa)    
Predicted Functional Partners:
gtsf-1
CHHC U11-48K-type domain-containing protein.
      
 0.808
pir-1
RNA/RNP complex-1-interacting phosphatase homolog; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity (By similarity). Binds RNA (By similarity). During small-RNA-mediated gene- silencing or RNA interference (RNAi), involved in the dcr-1-mediated processing of an amplified dsRNA intermediate.
   
  
 0.719
eri-9
RNase_Zc3h12a_2 domain-containing protein.
   
  
 0.712
eri-3
Enhanced RNAI (RNA interference).
   
  
 0.711
eri-5
Tudor domain-containing protein.
   
  
 0.702
dcr-1
Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily.
   
 
 0.698
eri-1
3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi.
   
 
 0.682
rmh-1
DUF1767 domain-containing protein.
   
    0.538
zim-3
Zinc finger In Meiosis.
   
    0.525
drh-1
Dicer-related helicase.
   
  
 0.469
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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