STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eri-12Enhanced RNAI (RNA interference). (674 aa)    
Predicted Functional Partners:
C43H6.4
Uncharacterized protein.
   
  
 0.791
F55C9.3
Uncharacterized protein.
      
 0.700
rde-10
RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets.
    
 
 0.685
ntl-9
NOT-Like (Yeast CCR4/NOT complex component).
      
 0.660
ubl-1
Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
      
 0.544
ccr-4
Endo/exonuclease/phosphatase domain-containing protein.
      
 0.538
sdha-2
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
      
 0.536
rde-12
DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1.
      
 0.469
mel-32
Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family.
      
 0.412
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.