STRINGSTRING
trx-2 protein (Caenorhabditis elegans) - STRING interaction network
"trx-2" - Probable thioredoxin-2 in Caenorhabditis elegans
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trx-2Probable thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (145 aa)    
Predicted Functional Partners:
exo-3
DNA-(apurinic or apyrimidinic site) lyase; Protein EXO-3, isoform a (288 aa)
   
 
  0.862
ape-1
Apoptotic enhancer 1 protein; Inhibitor of cep-1, which prevents the activation of apoptosis (769 aa)
           
  0.841
gsr-1
Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr-1, required for the reduction of disulfide groups in the cuticle during molting (473 aa)
   
 
  0.831
msra-1
Methionine Sulfoxide Reductase A; Protein MSRA-1 (msra-1) mRNA, complete cds (207 aa)
   
 
  0.817
prdx-3
Probable peroxiredoxin prdx-3; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily (226 aa)
   
 
  0.801
prdx-2
PeRoxireDoXin; Protein PRDX-2, isoform a (prdx-2) mRNA, complete cds (199 aa)
   
 
  0.801
F12F6.7
Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family (451 aa)
       
      0.792
fath-1
Fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids; Belongs to the cytochrome b5 family (316 aa)
     
 
  0.773
Y73B6BL.12
Thioredoxin; Protein Y73B6BL.12 (Y73B6BL.12) mRNA, complete cds; Belongs to the thioredoxin family (228 aa)
   
     
  0.768
T09A12.2
Glutathione peroxidase; Protein GPX-6, isoform b; Belongs to the glutathione peroxidase family (188 aa)
   
 
  0.760
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]